bySibley, Christopher R.; Seow, Yiqi; Saayman, Sheena; Dijkstra, Krijn K.; El Andaloussi, Samir; Weinberg, Marc S.; Wood, Matthew J. A.
This article is from Nucleic Acids Research , volume 40 . Abstract Mirtrons, short hairpin pre-microRNA (miRNA) mimics directly produced by intronic splicing, have recently been identified and experimentally confirmed in invertebrates. While there is evidence to suggest several mammalian miRNAs have mirtron origins, this has yet to be experimentally demonstrated. Here, we characterize the biogenesis of mammalian mirtrons by ectopic expression of splicing-dependent mirtron precursors. The... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245937